Paul Mallet

I am a behavioural neuroscientist who studies the behavioural and neural effects of drugs, with a special emphasis on drugs of abuse.

My research is focused on the brain’s endocannabinoid system. Using behavioural, pharmacological, and immunohistochemical techniques, I examine how cannabinoid receptors are involved in normal behaviour (e.g., learning, memory, feeding, locomotion), pathological behaviour (e.g., addiction). I also study the manner in which cannabinoid and non-cannabinoid drugs interact to alter behaviour and brain activity.

Note that I am not able to respond to elementary or high school students asking for information or an "expert opinion" related to their school assignments or projects.

I typically supervise student projects in the following areas (but other topics would be considered):

• Long-term consequences of cannabinoid system dysfunction caused by early life adversity.
• Role of the endocannabinoid system in learning and memory.
• Behavioural pharmacology of neutral CB1 receptor antagonists.
• Behavioural interactions between cannabinoid and non-cannabinoid drugs (e.g., ‘ecstasy’, nicotine, alcohol, heroin, cocaine).
• Involvement of endocannabinoids in drug reward and addiction.

I have already accepted several undergraduate and graduate students for the 2023-2024 academic year. Unfortunately I do not have the capacity to accept any additional honours thesis or graduate students for the 2023-2024 academic year.

• Manwell, L. A., Charachoglyan, A., Brewer, D., Matthews, B. A., Heipel, H. and Mallet, P. E. (2014). A vapourized ∆⁹-tetrahydrocannabinol (∆⁹-THC) delivery system part I: Development and validation of a pulmonary cannabinoid route of exposure for experimental pharmacology studies in rodents. Journal of Pharmacological and Toxicological Methods, 70, 120-127.
• Manwell, L. A., Ford, B., Matthews, B. A., Heipel, H. and Mallet, P. E. (2014). A vapourized ∆⁹-tetrahydrocannabinol (∆⁹-THC) delivery system part II: Comparison of behavioural effects of pulmonary versus parenteral cannabinoid exposure in rodents. Journal of Pharmacological and Toxicological Methods, 70, 112-119.
• Perit, K. E., Gmaz, J. M., Browne, J. D. C., Matthews, B. A., Dunn, M. B. F., Yang, L., Raaphorst, T., Mallet, P. E., and McKay, B. E. (2012). Distribution of c-Fos immunoreactivity in the rat brain following abuse-like toluene vapor inhalation. Neurotoxicoloy & Terotology, 34, 37-46.
• Quinn, H., Matsumoto, I., Callaghan, P. D., Long, L. E., Arnold, J. C., Gunasekaran, N., Thompson, M. R., Dawson, B., Mallet, P. E., Kashem, M. A., Matsuda-Matsumoto, H., Iwazaki, T. and McGregor, I. S. (2008). Adolescent rats find repeated Δ9-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure. Neuropsychopharmacology, 33, 1113-1126.
• O’Shea, M., McGregor, I. S. and Mallet, P. E. (2006). Repeated cannabinoid exposure during perinatal, adolescent, or early adult ages produces similar long-lasting deficits in object recognition and reduced social interaction in rats. Journal of Psychopharmacology, 20, 611-621.
• Singh, M. E., McGregor, I. S. and Mallet, P. E. (2006). Perinatal exposure to ∆9-tetrahydrocannabinol alters heroin-induced place conditioning and Fos-immunoreactivity. Neuropsychopharmacology, 31, 58-69.
• Morley, K.C., Li, K.M., Hunt, G.E., Mallet, P.E. & McGregor, I.S. (2004). Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ('Ecstasy') in rats. Neuropharmacology, 46, 954-965.

I presently teach:

• PS263 Behavioural Neuroscience
• PS268 Drugs and Behaviour
• PS363 Research in Behavioural Neuroscience

Kelly ALLEN (2001) - Fourth year honours student
Joshua BARBER (2010-2011) - High school intern
Melissa BEACROFT (2000) - Fourth year honours student
Jon BEHICH (2008) - Directed studies student
Melissa COLLIE (2002) - Fourth year honours student
Saraswati CROFT (2002) - Fourth year honours student
Marshall DALTON (2004) - Fourth year honours student
Caroline DIORIO (2009) - Directed studies student
Brittany FORD (2007-2010) - Fourth year honours + M.Sc. student
Laura FLANNERY (2006-2007) - High school intern
Andrew GARDNER (2005) - Fourth year honours student
Karen GLYNN (2005) - Fourth year honours student
Peter GOARD (2004) - Fourth year honours student
Kelly GUEST (2007-2008) - Fourth year honours + directed studies student
Louise HANSON (2005) - Fourth year honours student
Dr. Tanya HANSTOCK (2001-2003) - DPsych (Clinical & Health) student
Jessica HATCH (2010-2011) - Fourth year honours student
Linda HAYES (2005) - Fourth year honours student
Heather HEIPEL (2007-2008) - Fourth year honours student
Cynthia HONAN (2005) - Fourth year honours student
Jennifer IRLE (2003) - Fourth year honours student
Sarah LIST (2008) - Directed studies student
Paul MACLACHLAN (2006-2007) - Fourth year honours student
Brittany MATTHEWS (2008-2009) - Fourth year honours student
Clinton MOORE (2003) - Fourth year honours student
Anna MOULYNOX (2001-2002) - Fourth year honours student
Melanie O'SHEA (2001-2005) - MSc and PhD student
Talei PARKER (2003-2008) - Fourth year honours and PhD student
Bethany PAYETTE (2009-2010) - Research assistant + fourth year honours student
Simmone POULIOS (2004) - Fourth year honours student
Tanya RAAPHORST (2008-2011)- Fourth year honours + M.Sc. student
Dr. Shadna RANA (2007-2009) - Postdoctoral researcher
Dr. Elham SATVAT (2006-2009) - PhD student
Jordan SCANTLEBURY (2006-2007) - Fourth year honours student
Marc SCHAUS (2009) - Directed studies student
Andrea SCHNEIDER (2007-2008) - Fourth year honours student
Dr. Malini SINGH (1999-2005) - Fourth year honours + PhD student
Karen SMITH (2004) - Fourth year honours student
Steven UNDERWOOD (2001) - Fourth year honours student
Dr. Aaron VERTY (2000-2004) - PhD student
Sarah VOLL (2009-2011) - Fourth year honours student + research assistant
Narendra WARTY (1999-2001) - MA student
Jodie WONSACK (2001) - Fourth year honours student
June YOUNG (2001-2008) - PhD student