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I received my PhD in Biochemistry from the University of British Columbia in 2008 and my MSc in Chemistry from McGill University in 2002.
Prior to joining Laurier, I was a postdoctoral fellow in the School of Pharmacy at the University of Wisconsin-Madison (2008-2011).
My primary research interest is how microorganisms synthesize small molecule natural products such as antibiotics. To combat increasing antibiotic resistance, the vast reservoir of chemical diversity in nature can provide new compounds and targets for next generation therapeutics. Novel biosynthetic pathways are also a rich source of highly stereo- and regioselective enzymes that can enable low emission, or “green” industrial chemical syntheses.
- Natural Sciences and Engineering Research Council Postdoctoral Fellowship Award (2008-10).
Research opportunities are available for motivated trainees interested in working at the chemistry-biology interface. We are currently recruiting graduate and postdoctoral positions. Please send a cover letter and your CV to ghorsman@wlu.ca.
- Ramos-Figueroa JS, Palmer DRJ, Horsman GP (2022) "Phosphoenolpyruvate mutase-catalyzed C–P bond formation: mechanistic ambiguities and opportunities" ChemBioChem, in press.
- Li S, Horsman GP (2022) "An inventory of early branch points in microbial phosphonate biosynthesis" Microbial Genomics, 8:000781.
- Li P, Chen M, Tang W, Guo Z, Zhang Y, Wang M, Horsman GP, et al. (2021) "Initiating polyketide biosynthesis by on-line methyl esterification" Nature Communications, 12:4499.
- Ding Y, Li X, Horsman GP, et al. (2021) "Contruction of an alternative NAD+ de novo biosynthesis pathway" Advanced Science, 8:2004632
- Wang D, Qi J, Han W, Gao JM, Horsman GP (2020) "Kanamycin-induced production of 2',3'-cyclic AMP in E. coli" Biochemical and Biophysical Research Communications, 527:854.
- Yan Y, Yang J, Wang L, et al. (2020) "Biosynthetic access to the rare antiarose sugar via an unusual reductase-epimerase" Chemical Science, 11:3959.
- Rice K, Batul K, Whiteside J, Kelso J, Papinski M, Schmidt E, Pratasouskaya A, Wang D, Sullivan R, Bartlett C, Weadge JT, Van der Kamp MW, Moreno-Hagelsieb G, Suits MD, Horsman GP (2019) "The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis" Nature Communications, 10:3698.
- Hao T, Xie Z, Wang M, Liu L, Zhang Y, Wang W, Zhang Z, Zhao X, Li P, Guo Z, Luo C, Zhang G, Merritt J, Horsman GP, Chen Y (2019) "An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters" Nature Communications, 10:3665.
- Huitema C, Horsman GP (2018) "Analyzing enzyme kinetic data using the powerful statistical capabilities of R" bioRxiv, DOI: 10.1101/316588
- Guo X, Crnovcic I, Chang C-Y, Luo J, Lohman J, Papinski M, Bechthold A, Horsman G, Shen B (2018) "PokMT1 from the polyketomycin biosynthetic machinery of Streptomyces diastatochromogenes Tu6028 belongs to the emerging family of C-methyltransferases that act on CoA-activated aromatic substrates" Biochemistry, 57:1003.
- Bartlett C, Bansal S, Burnett A, Suits MD, Schaefer J, Cegelski L, Horsman GP, Weadge JT (2017) "Whole-cell detection of C-P bonds in bacteria" Biochemistry, 56:5870.
- Horsman GP, Zechel DL (2017) "Phosphonate Biochemistry" Chemical Reviews 117: 5704-5783.
- Liu L, Hao T, Xie Z, Horsman GP, Chen Y (2016) "Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans." Scientific Reports, 6:37479.
- Yan Y, Yang J, Yu Z, Yu M, Ma Y-T, Wang L, Su C, Luo J, Horsman GP, Huang S-X (2016) "Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids." Nature Communications 7:13083.
- Yan Y, Ma Y-T, Yang J, Horsman GP, Luo D, Ji X, Huang S-X (2016) "Tropolone ring construction in the biosynthesis of rubrolone B, a cationic tropolone alkaloid from endophytic Streptomyces." Organic Letters 18:1254-1257.
- Chi MC, Horsman GP (2015) "Evaporative light scattering quantification of natural products possessing a carbon-phosphorus bond." Journal of Antibiotics, 68:752-756.
- Horsman GP, Lechner A, Ohnishi Y, Moore BS, Shen B (2013) “Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of 9-membered enediyne antitumor antibiotics.” Biochemistry, 52:5217-5224. **Highlighted on the Biochemistry journal homepage.
- Ruzzini A, Ghosh S, Horsman GP, Foster L, Bolin JT, Eltis LD (2012) “Identification of an acyl-enzyme intermediate in a meta-cleavage product hydrolase reveals the versatility of the catalytic triad.” J. Am. Chem. Soc., 134:4615-4624.
- Horsman GP, Chen Y, Thorson JS, Shen B (2010) “Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes.” Proc. Natl. Acad. Sci. USA 107:11331-11335. A news report describing this work appeared in Chemical & Engineering News (June 14, 2010) 88(24):39.
Contact Info:
Office location: BA409
Languages spoken: English