Chemistry and Biochemistry
Dr. Dmitri Gusev Greener Methods: Ester Hydrogenation
Dr. Gusev's lab is featured on Sigma-Aldrich's website. The reduction of esters to alcohols is typically accomplished using metal hydrides. While effective, this widely used method comes at the cost of stoichiometric waste and often complicated workup procedures that can be particularly time consuming on scale.
In 2012 and 2013, Gusev and coworkers reported Ru-PNN and Ru-SNS complexes (746347 and 746339) new ruthenium catalysts that enable ester hydrogenation with unprecedented efficiency and activity at low temperature.
Sigma-Aldrich is proud to offer a number of metal complexes that catalyze the reduction of esters with hydrogen gas, increasing atom efficiency and eliminating the labor intensive workup that accompanies metal hydride reductions.
For details, the Gusev Group is featured on Sigma-Aldrich professor portal.