About the laboratory for Neural Computation, Ageing, and Memory (NCAM)
Research in NCAM seeks to provide a more complete understanding of the cellular and molecular mechanisms involved in cognition and enduring memory formation, with emphasis on how these mechanisms are compromised with advancing age.
While medical progress has made it possible for succeeding generations to live longer, discernible cognitive impairment (i.e., memory loss) will afflict a substantial proportion of the elderly, even in the absence of neurodegenerative disease. Thus, determining the nature and causes of this cognitive impairment has become a major challenge in the study of aging. While it was once thought that neuron loss was an inevitable consequence of aging, recent research has demonstrated that the number of neurons in components of the medial temporal lobe is comparable in young vs. aged mammals, including humans. Thus, the critical challenge is to uncover other, physiological factors that must cause cognitive impairment in aging.
Experimental approaches for these investigations include: