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Wilfrid Laurier University Leaf
November 25, 2014

Canadian Excellence

Lillian DeBruin



Contact:

email: Lillian DeBruin
phone: 519 884-0710
ext: 3599


Publications



Peer-reviewed Journals

DeBruin, L.S., and Harauz G., White matter rafting Membrane microdomains in myelin. Neurochem. Res. 32, 213-28 (2007) [link]

DeBruin, L.S., Haines, J.D., Bienzle, D. and Harauz G., Partitioning of myelin basic protein into membrane microdomains in a spontaneously demyelinating mouse model for multiple sclerosis. Biochem. Cell Biol. 84, 933-1005 (2006) [link]

DeBruin, L.S., Haines, J.D., Wellhauser, L.A., Radeva, G., Schonmann, Bienzle, D. and Harauz G. The developmental partitioning of myelin basic protein into membrane microdomains. J. Neurosci. Res. 80, 211-25 (2005) [link]

Josephy, P.D., Summerscales, J., DeBruin, L.S., Schlaeger, C., and Ho, J. N-Hydroxyarylamine O-acetyltransferase-deficient Escherichia coli strains are resistant to the mutagenicity of nitro compounds. Biol. Chem. 383, 977-982 (2002)

DeBruin, L.S., and Josephy, P.D., Breast cancer and environmental factors. Environ. Health Perspect. Suppl. 1, 119-128 (2002) [link]

DeBruin, L.S., Martos, P.A., and Josephy, P.D., Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the milk of healthy women. Chem. Res.Toxicol. 14, 153-1528 (2001) [link]

DeBruin, L.S., Pawliszyn, J.B., and Josephy, P.D., Detection of monocyclic aromatic amines, possibly mammary carcinogens, in human breast milk. Chem. Res.Toxicol. 12, 78-82 (1999) [link]

DeBruin, L.S., Josephy, P.D., and Pawliszyn, J.B., Solid-phase microextraction of monocyclic aromatic amines from biological fluids. Anal. Chem. 70, 1986-1992 (1998)

Josephy, P.D., DeBruin, L.S., Lord, H.L., Oak, J.N., Evans, D.H., Guo, Z., Dong, M-S., and Guengerich, F.P., Bioactivation of aromatic amines by recombinant human cytochrome P4501A2 expressed in Ames tester strain bacteria: A substitute for activation by mammalian tissue preparations. Cancer Res. 55, 799-802 (1995) [link]

Smith, B.J., DeBruin, L., Josephy, P.D., and Eling, T.E., Mutagenic activation of benzidine requires prior bacterial acetylation and subsequent conversion by prostaglandin H synthase to 4-nitro-4-(acetylamino)biphenyl. Chem. Res. Toxicol. 5, 431-439 (1992)

DeBruin, L.S., and Josephy, P.D., Dichlorobenzidine DNA binding catalyzed by peroxidative activation in Salmonella typhimurium. Arch. Biochem. Biophys. 269, 25-31 (1989)

Conference Presentations

DeBruin, L.S., Haines, J.D., LaForest, A., Harauz G., Developmental partitioning of MBP into myelin microdomains. The 36th Annual Meeting of the American Society for Neurochemistry, Madison, Wisconsin, USA, 25-29 June 2005. J. Neurochem. 94 (supplement 1) abstract PSM08-04.

DeBruin, L.S., Haines, J.D., Wood, D.D., Moscarello, M.A., Harauz, G., Distribution and post- translational modifications of myelin basic protein isoforms during myelinogenesis in the foetal calf. The 34th Annual Meeting of the American Society for Neurochemistry, Newport Beach, California, USA, 3-8 May 2003. J. Neurochem. 85 (supplement 1) abstract BP03-01.

DeBruin, L.S., Wood, D.D., Moscarello, M.A., and Harauz, G., Interactions between myelin basic protein (MBP) and SH3 domain proteins, ESF Exploratory Workshop on Myelin Structure and its Role in Autoimmunity, Potenza (Basilicata), Italy, June 5-8, 2002.

DeBruin, L.S., Josephy, P.D., and Pawliszyn, J., Determination of heterocyclic aromatic amine levels in human milk samples by a rapid solid-phase extraction method, Environmental and Molecular Mutagenesis 35 (Suppl. 31): abstract #43, 2000 (31st Annual Meeting, Environmental Mutagen Society, New Orleans, LA, USA, April 9-13).

Lord, H., DeBruin, L., Kataoka, H., Josephy, D., and Pawliszyn, J., Analysis of monocyclic and heterocyclic aromatic amines by fiber SPME/GC/FID and in-tube SPME/LC/MS, 2000 Pittsburgh Conference, Abstract #426, New Orleans, LA, USA, March 12-17, 2000.

DeBruin, L.S., Pawliszyn, J.B., and Josephy, P.D., Detection of monocyclic aromatic amines, possible mammary carcinogens, in human milk, Society of Toxicology of Canada, 31st annual meeting, Montreal, Dec. 1998.

Josephy, P.D., DeBruin, L.S., and Pawliszyn, J., Aromatic amine mammary carcinogens: human exposure assessment and mechanisms of activation, Environmental and Molecular Mutagenesis 31 (Suppl. 29): abstract S10.4, 1998 (29th Annual Meeting, Environmental Mutagen Society, Anaheim, CA, USA, March 21-26).

DeBruin, L.S., Josephy, P.D., Kingsmill, C.A., Pawliszyn, J., and Atkinson, S.A., Detection of aromatic amines in human milk, Proc. Amer. Assoc. Cancer Res. 38, abstract #2359, 1997 (AACR annual meeting, San Diego, CA, 1997).

DeBruin, L.S., Josephy, P.D., Kingsmill, C.A., Pawliszyn, J., and Atkinson, S.A., Environmental aromatic amines in human milk A role in breast cancer? Society of Toxicology of Canada, 29th annual meeting, Montreal, Dec. 1996.

Josephy, P.D., Stober, D., DeBruin, L.S., Kingsmill, C.A., Atkinson, S.A., Pawliszyn, J., Sipe Jr., H.J., and Mason, R.P., Environmental aromatic amines as human mammary carcinogens, Carcinogenesis from Environmental Pollution: Assessment of human risk and strategies for prevention, American Association for Cancer Research/ Int'l Agency for Research on Cancer, Special Meeting, Budapest, Hungary, Oct. 6 9, 1996

Josephy, P.D., DeBruin, L.S., Lord, H.L., Oak, J.N., Evans, D.H., Guo, Z., Dong, M. S., and Guengerich, F.P., Bioactivation of aromatic amines by recombinant human cytochrome P450 1A2 expressed in Ames tester strain bacteria: a substitute for activation by mammalian tissue preparations, Proc. Amer. Assoc. Cancer Res. 36, abstract #958, 1995 (AACR annual meeting, Toronto, 1995).

DeBruin, L.S., and Josephy, P.D., Horseradish peroxidase (HRP) activates benzidine to a mutagen in a modified ames assay. Can. Fed. Biol. Soc. meeting, Kingston, June 1991

Smith, W.J., Eling, T.E., DeBruin, L., and Josephy, P.D., The role of bacterial acetylation in the activation of benzidine by prostaglandin H synthase (PHS): metabolism and mutagenicity studies. The Toxicologist: 11 (Society of Toxicology, 1991 annual meeting, Dallas)