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December 22, 2014

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Lucy Lee

Establishment of cell cultures from the gastrointestinal tract of Atlantic salmon, Salmo salar

Bulletin MDIBL 48: 55-58
Lee, L.E.J., A. Kawano, B. Inthavong, B. Dixon and N.C. Bols

published: 2009 | Research publication | Recent Publications

The physiology of the gastrointestinal tract (GI) of fish is of interest in both basic and applied research. One applied interest is in the development of new fish feeds for aquaculture. The current practice of using fish meal in fish feed is not sustainable in the long run, and there is an interest in using plant meals as a replacement. However, for one of the most lucrative aquaculture species, the Atlantic salmon (Fig. 1), the most attractive plant substitute, soybean meal, causes enteritis2,17. Enteritis is inflammation of the intestine and ultimately impairs growth. Identifying the causative agents in soybean meal for enteritis could lead to ways of eliminating them and making soybean meal an alternative to fish meal. One way of rapidly screening soybean meal components for their potential to cause inflammation is to use cell cultures from the fish GI tract, especially cell lines that can be grown continuously and thus be a stable source of cells for experimentation. Greater availability of fish GI cell cultures also would enhance the study of drug interactions, toxicants and gut pathogens with intestinal enterocytes.

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revised Aug 27/09

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