Combined low dose treatment with opioid and cannabinoid receptor antagonists synergistically reduces alcohol craving and alcohol consumption in rats
Psychopharmacology, 173, 210-216.
Gallate, J., Mallet, P.E. & McGregor, I.S.
published: 2004 | Research publication | Journal article
Abstract: RATIONALE: Opioid and cannabinoid CB(1) receptor antagonists reduce the motivation to consume alcohol when taken individually but their effectiveness in combination is not yet known. OBJECTIVE: The effects of naloxone/naltrexone and SR 141716 alone and in combination were examined on beer consumption in rats. METHODS: In a progressive ratio paradigm rats were trained to lick at a tube for either beer (4.5% ethanol v/v) or near-beer (beer containing
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