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Wilfrid Laurier University Leaf
July 26, 2016

Canadian Excellence


Paul Mallet

Combined low dose treatment with opioid and cannabinoid receptor antagonists synergistically reduces alcohol craving and alcohol consumption in rats

Psychopharmacology, 173, 210-216.
Gallate, J., Mallet, P.E. & McGregor, I.S.

published: 2004 | Research publication | Journal article

Abstract:RATIONALE: Opioid and cannabinoid CB(1) receptor antagonists reduce the motivation to consume alcohol when taken individually but their effectiveness in combination is not yet known. OBJECTIVE: The effects of naloxone/naltrexone and SR 141716 alone and in combination were examined on beer consumption in rats. METHODS: In a progressive ratio paradigm rats were trained to lick at a tube for either beer (4.5% ethanol v/v) or near-beer (beer containing

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revised Jan 20/06

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