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Paul Mallet

?9-THC reinstates beer- and sucrose-seeking behaviour in abstinent rats: Comparison with midazolam, food deprivation and predator odor

Alcohol & Alcoholism, 40, 35-45.
McGregor, I.S., Dam, K.D.B., Mallet, P.E. & Gallate, J.E.

published: 2005 | Research publication | Journal article

Abstract: Aims: Recent studies suggest that cannabinoid receptor agonists may promote relapse to drug-seeking behaviour after a period of abstinence. In this study, the ability of ?9-tetrahydrocannabinol (THC) to reinstate previously reinforced responding for alcoholic and non-alcoholic beverages was assessed in rats using a novel lick-based paradigm. Methods: Rats were initially given free access to beer (containing 4.5% ethanol v/v), near-beer (a beverage that looks and tastes like beer but contains

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revised Jan 20/06

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